• For many who look to stem cells as a means

  2018-11-08

  

  For many who look to stem l-ascorbic acid as a means to alleviate their suffering, or that of their loved one, such high expectations are unlikely to be met in the near future. Although the number of clinical trials for novel applications of stem cells has risen rapidly since 2004 (Li et al, 2013),

• Until recently a paucity of

  2018-11-08

  

  Until recently, a paucity of understanding about the cellular homeostasis of most adult solid tissues has been a major factor limiting the expansion to other areas of medicine of the early breakthroughs in adult stem cell research and therapy, such as those applied to the blood and bone marrow disea

• Pluripotency tests included flow cytometry analysis of prote

  2018-11-08

  

  Pluripotency tests included flow cytometry analysis of protein stem cell markers SSEA3, SSEA4, Tra1-60, Tra1-81 and Oct3/4 (Fig. 2A), alkaline phosphatase staining (ALP) (Fig. 2B), and qRT-PCR analysis of endogenous pluripotent transcription factors OCT-4, SOX-2, NANOG and REX1 (Fig. 2C). To finally

• br Conflict of interest br Acknowledgments

  2018-11-08

  

  Conflict of interest Acknowledgments Introduction In order to understand the molecular and physiological changes in neurons of the brains of individuals with disorders ranging from intellectual disability to autism, it is essential to study live neurons that accurately represent the conditi

• Using ESNPs to repair damaged tissue in neurodegenerative

  2018-11-08

  

  Using ESNPs to repair damaged tissue in neurodegenerative diseases is an attractive option, as these Angiogenesis Compound Library are more readily obtained than fetal material. Recent work on the relationship between neural stem cells and blood vessels (reviewed in (Bjornsson et al., 2015) as well

• Despite these achievements in iNSC

  2018-11-08

  

  Despite these achievements in iNSC technology, little is known on how cellular identities of iNSCs differ from those of NSCs in comparison to pluripotent stem cell-derived NPCs. For instance, it is currently unknown to what extent neural, metabolic and stress response pathways differ between these n

• Despite these achievements in iNSC

  2018-11-08

  

  Despite these achievements in iNSC technology, little is known on how cellular identities of iNSCs differ from those of NSCs in comparison to pluripotent stem cell-derived NPCs. For instance, it is currently unknown to what extent neural, metabolic and stress response pathways differ between these n

• The induced expression of hADC was confirmed

  2018-11-08

  

  The induced expression of hADC was confirmed by immunostaining and western blotting (Fig. 1A&B). The over-expression of hADC genes significantly increased endogenous agmatine (Fig. 1C). Adherence of conotoxin is important for differentiation as well as for proliferation, migration, neurite outgrowt

• miR expression was strikingly down

  2018-11-08

  

  miR-410 expression was strikingly down-regulated in the adult SVZ following Noggin over-expression in our inducible transgenic mice (Morell et al., 2015). Noggin was initially characterized by its ability to rescue the phenotype of UV light-dorsalized embryos (Smith and Harland, 1992; Lamb et al., 1

• br Materials and methods br Author disclosure statement br

  2018-11-08

  

  Materials and methods Author disclosure statement Acknowledgments This study was supported by fund from National Medical Research Council (NMRC) of China to SZ (fund number: 30400447) and HW (fund number: 30500548). Resource table. Resource details To engineer a biallelic mutation in t

• Other cell extrinsic mechanisms may lead

  2018-11-08

  

  Other cell-extrinsic mechanisms may lead to a progressive loss of WT CB-5083 through an active process that eliminates the least fit populations. Such processes occur during normal development in the mammalian embryo, in which relatively unfit populations are deleted through apoptosis (Clavería et a

• br Experimental Procedures br Author

  2018-11-08

  

  Experimental Procedures Author Contributions Acknowledgments Introduction We recently described an animal model in which primary genetic lesions in bone marrow (BM) stromal purchase 5-Azacytidine resulted in abnormal hematopoiesis in mice and the rare development of acute leukemia (Raai

• Although GPX is known as a gastrointestinal GSH peroxidase

  2018-11-08

  

  Although GPX2 is known as a gastrointestinal GSH peroxidase, it also is expressed in other tissues (Brigelius-Flohé and Kipp, 2012). Interestingly, its expression level is increased in intestinal crypt stem cells and malignant epithelial cells, suggesting a role in proliferation and self-renewal. It

• Data generated from GSEA DAVID

  2018-11-08

  

  Data generated from GSEA, DAVID and gene hierarchical clustering of sorted stem and committed progenitor cell transcriptomes provides an opportunity to explore processes that govern prostate stem cell biology, self-renewal and differentiation. One notable enrichment in active stem proton pump inhibi

• br Results br Discussion FLT and

  2018-11-08

  

  Results Discussion FLT3 and KIT are key RTKs controlling HSPCs. Ubiquitination and dephosphorylation are two important mechanisms to negatively regulate RTK signaling (Dikic and Giordano, 2003; Sastry and Elferink, 2011). These data are in agreement with observations made in CBL and Itch knoc

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